Targeting Plasmodium PI(4)K to eliminate malaria

Plasmodium vivax: a roadblock on the quest to eliminate malaria.

On World Malaria Day, a Push to Eliminate Malaria

The efficacy of the tools that secured the gains against malaria in the early years of this century is now threatened. Mosquito resistance to insecticides used in nets and indoor residual spraying is growing. So too is parasite resistance to a component of one of the most powerful antimalarial medicines. Further progress against malaria will likely require new tools that do not exist today, and...

Targeting the shikimate pathway in the malaria parasite Plasmodium falciparum.

The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6R)-6-Fluoro-shikimate and (6S)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 x 10(-5) and 2.7 x 10(-4) M, respectively), whereas 2-fluoro-shikimate had no effect. para-Aminobenzoic acid abrogated the in...

Targeting NAD+ Metabolism in the Human Malaria Parasite Plasmodium falciparum

Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite utilized as a redox cofactor and enzyme substrate in numerous cellular processes. Elevated NAD+ levels have been observed in red blood cells infected with the malaria parasite Plasmodium falciparum, but little is known regarding how the parasite generates NAD+. Here, we employed a mass spectrometry-based metabolomic approach to...

cerebellar malaria due to plasmodium vivax in a child

infection resulting from plasmodium vivax is the commonest type found in india as well as other tropical regions. the clini­cal picture is variable depending on the nature, immunity of the child, and lives in an endemic area or not. here, we report a child, who presented with cerebellar dysfunction with intact sensorium and plasmodium vivax was positive on peripheral smear.